Ontology highlight
ABSTRACT:
SUBMITTER: Nautiyal KM
PROVIDER: S-EPMC4431594 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nautiyal Katherine M KM Tanaka Kenji F KF Barr Mary M MM Tritschler Laurent L Le Dantec Yannick Y David Denis J DJ Gardier Alain M AM Blanco Carlos C Hen René R Ahmari Susanne E SE
Neuron 20150416 3
Impulsive and aggressive behaviors are both modulated by serotonergic signaling, specifically through the serotonin 1B receptor (5-HT1BR). 5-HT1BR knockout mice show increased aggression and impulsivity, and 5-HT1BR polymorphisms are associated with aggression and drug addiction in humans. To dissect the mechanisms by which the 5-HT1BR affects these phenotypes, we developed a mouse model to spatially and temporally regulate 5-HT1BR expression. Our results demonstrate that forebrain 5-HT1B hetero ...[more]