Ontology highlight
ABSTRACT:
SUBMITTER: Pooya S
PROVIDER: S-EPMC4431623 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Pooya Shabnam S Liu Xiaona X Kumar V B Sameer VB Anderson Jane J Imai Fumiyasu F Zhang Wujuan W Ciraolo Georgianne G Ratner Nancy N Setchell Kenneth D R KD Yoshida Yutaka Y Jankowski Michael P MP Dasgupta Biplab B
Nature communications 20140926
A prerequisite to myelination of peripheral axons by Schwann cells (SCs) is SC differentiation, and recent evidence indicates that reprogramming from a glycolytic to oxidative metabolism occurs during cellular differentiation. Whether this reprogramming is essential for SC differentiation, and the genes that regulate this critical metabolic transition are unknown. Here we show that the tumour suppressor Lkb1 is essential for this metabolic transition and myelination of peripheral axons. Hypomyel ...[more]