Ontology highlight
ABSTRACT:
SUBMITTER: Yamanaka Y
PROVIDER: S-EPMC4431949 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Yamanaka Yasunari Y Faghihi Mohammad Ali MA Magistri Marco M Alvarez-Garcia Oscar O Lotz Martin M Wahlestedt Claes C
Cell reports 20150430 6
Long non-coding RNAs (lncRNAs), including natural antisense transcripts (NATs), are expressed more extensively than previously anticipated and have widespread roles in regulating gene expression. Nevertheless, the molecular mechanisms of action of the majority of NATs remain largely unknown. Here, we identify a NAT of low-density lipoprotein receptor-related protein 1 (Lrp1), referred to as Lrp1-AS, that negatively regulates Lrp1 expression. We show that Lrp1-AS directly binds to high-mobility g ...[more]