Ontology highlight
ABSTRACT:
SUBMITTER: Hing ZA
PROVIDER: S-EPMC4432007 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Hing Zachary A ZA Mantel Rose R Beckwith Kyle A KA Guinn Daphne D Williams Erich E Smith Lisa L LL Williams Katie K Johnson Amy J AJ Lehman Amy M AM Byrd John C JC Woyach Jennifer A JA Lapalombella Rosa R
Blood 20150402 20
Despite the therapeutic efficacy of ibrutinib in chronic lymphocytic leukemia (CLL), complete responses are infrequent, and acquired resistance to Bruton agammaglobulinemia tyrosine kinase (BTK) inhibition is being observed in an increasing number of patients. Combination regimens that increase frequency of complete remissions, accelerate time to remission, and overcome single agent resistance are of considerable interest. We previously showed that the XPO1 inhibitor selinexor is proapoptotic in ...[more]