Ontology highlight
ABSTRACT:
SUBMITTER: Nakasone H
PROVIDER: S-EPMC4432013 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nakasone Hideki H Tian Lu L Sahaf Bita B Kawase Takakazu T Schoenrock Kelsi K Perloff Spenser S Ryan Christine E CE Paul Jed J Popli Rakesh R Wu Fang F Otani Joanne M JM Coller John J Warren Edus H EH Miklos David B DB
Blood 20150312 20
Allogeneic antibodies against minor histocompatibility antigens encoded on the Y chromosome (HY-Abs) develop after hematopoietic cell transplant (HCT) of male recipients with female donors (F→M). However, the temporal association between HY-Ab development and chronic graft-versus-host disease (cGVHD) has yet to be elucidated. We studied 136 adult F→M HCT patients, with plasma prospectively collected through 3 years posttransplant, and measured immunoglobulin G against 6 H-Y antigens. Multiple HY ...[more]