Ontology highlight
ABSTRACT:
SUBMITTER: Hott A
PROVIDER: S-EPMC4432152 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hott Amanda A Casandra Debora D Sparks Kansas N KN Morton Lindsay C LC Castanares Geocel-Grace GG Rutter Amanda A Kyle Dennis E DE
Antimicrobial agents and chemotherapy 20150316 6
Artemisinin derivatives are used in combination with other antimalarial drugs for treatment of multidrug-resistant malaria worldwide. Clinical resistance to artemisinin recently emerged in southeast Asia, yet in vitro phenotypes for discerning mechanism(s) of resistance remain elusive. Here, we describe novel phenotypic resistance traits expressed by artemisinin-resistant Plasmodium falciparum. The resistant parasites exhibit altered patterns of development that result in reduced exposure to dru ...[more]