Ontology highlight
ABSTRACT:
SUBMITTER: Eldholm V
PROVIDER: S-EPMC4432642 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Eldholm Vegard V Monteserin Johana J Rieux Adrien A Lopez Beatriz B Sobkowiak Benjamin B Ritacco Viviana V Balloux Francois F
Nature communications 20150511
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a major public health issue. Here we reconstruct the timeline of the acquisition of antimicrobial resistance during a major ongoing outbreak of multidrug-resistant TB in Argentina. We estimate that the progenitor of the outbreak strain acquired re ...[more]