Ontology highlight
ABSTRACT:
SUBMITTER: Chiu KW
PROVIDER: S-EPMC4432787 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chiu King-Wah KW Nakano Toshiaki T Chen Kuang-Den KD Hsu Li-Wen LW Lai Chia-Yun CY Huang Ching-Yin CY Cheng Yu-Fan YF Goto Shigeru S Chen Chao-Long CL
Journal of biomedical science 20150515
Cytochrome P450 metabolizes many drugs in the liver. Three genotypes of CYP2C19 with extensive, intermediate, and poor metabolizing activity, respectively, have been identified in peripheral blood of transplant recipients and new liver grafts in living donor liver transplantation (LDLT). The expression of the final genotype in liver graft biopsies depends on the donor, whereas the expression in peripheral blood mononuclear cells depends on the recipient. The metabolizing isoenzyme of the major a ...[more]