Ontology highlight
ABSTRACT:
SUBMITTER: Mullen LM
PROVIDER: S-EPMC4432834 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Mullen Lisa M LM Chamberlain Giselle G Sacre Sandra S
Arthritis research & therapy 20150515
The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of inflammation. Inadvertent activation of pattern recognition receptors has been proposed to contribute to the pathogenesis of many conditions including inflammatory rheumatic diseases. Prolonged inflammation most often results in pain and damage to ti ...[more]