Ontology highlight
ABSTRACT:
SUBMITTER: Chung WC
PROVIDER: S-EPMC4433236 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Chung Woo-Chang WC Kang Hye-Ri HR Yoon Hyunyee H Kang Suk-Jo SJ Ting Jenny P-Y JP Song Moon Jung MJ
PloS one 20150515 5
The inflammasome is a molecular platform that stimulates the activation of caspase-1 and the processing of pro-interleukin (IL)-1β and pro-IL-18 for secretion. The NOD-like receptor family, pyrin domain containing 3 (NLRP3) protein is activated by diverse molecules and pathogens, leading to the formation of the NLRP3 inflammasome. Recent studies showed that the NLRP3 inflammasome mediates innate immunity against influenza A virus (IAV) infection. In this study, we investigated the function of th ...[more]