Ontology highlight
ABSTRACT:
SUBMITTER: Mastorakos P
PROVIDER: S-EPMC4433405 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Mastorakos Panagiotis P Zhang Clark C Berry Sneha S Oh Yumin Y Lee Seulki S Eberhart Charles G CG Woodworth Graeme F GF Suk Jung Soo JS Hanes Justin J
Advanced healthcare materials 20150311 7
Gene delivery to the central nervous system (CNS) has potential as a means for treating numerous debilitating neurological diseases. Nonviral gene vector platforms are tailorable and can overcome key limitations intrinsic to virus-mediated delivery; however, lack of clinical efficacy with nonviral systems to date may be attributed to limited gene vector dispersion and transfection in vivo. It is shown that the brain extracellular matrix (ECM) strongly limits penetration of polymer-based gene vec ...[more]