Dataset Information

HIV status and the risk of ischemic stroke among men.

ABSTRACT:

Objective

Given conflicting data regarding the association of HIV infection and ischemic stroke risk, we sought to determine whether HIV infection conferred an increased ischemic stroke risk among male veterans.

Methods

The Veterans Aging Cohort Study-Virtual Cohort consists of HIV-infected and uninfected veterans in care matched (1:2) for age, sex, race/ethnicity, and clinical site. We analyzed data on 76,835 male participants in the Veterans Aging Cohort Study-Virtual Cohort who were free of baseline cardiovascular disease. We assessed demographics, ischemic stroke risk factors, comorbid diseases, substance use, HIV biomarkers, and incidence of ischemic stroke from October 1, 2003, to December 31, 2009.

Results

During a median follow-up period of 5.9 (interquartile range 3.5-6.6) years, there were 910 stroke events (37.4% HIV-infected). Ischemic stroke rates per 1,000 person-years were higher for HIV-infected (2.79, 95% confidence interval 2.51-3.10) than for uninfected veterans (2.24 [2.06-2.43]) (incidence rate ratio 1.25 [1.09-1.43]; p < 0.01). After adjusting for demographics, ischemic stroke risk factors, comorbid diseases, and substance use, the risk of ischemic stroke was higher among male veterans with HIV infection compared with uninfected veterans (hazard ratio 1.17 [1.01-1.36]; p = 0.04).

Conclusions

HIV infection is associated with an increased ischemic stroke risk among HIV-infected compared with demographically and behaviorally similar uninfected male veterans.

SUBMITTER: Sico JJ

PROVIDER: S-EPMC4433456 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Publications

HIV status and the risk of ischemic stroke among men.

Sico Jason J JJ Chang Chung-Chou H CC So-Armah Kaku K Justice Amy C AC Hylek Elaine E Skanderson Melissa M McGinnis Kathleen K Kuller Lewis H LH Kraemer Kevin L KL Rimland David D Bidwell Goetz Matthew M Butt Adeel A AA Rodriguez-Barradas Maria C MC Gibert Cynthia C Leaf David D Brown Sheldon T ST Samet Jeffrey J Kazis Lewis L Bryant Kendall K Freiberg Matthew S MS

Neurology 20150410 19

<h4>Objective</h4>Given conflicting data regarding the association of HIV infection and ischemic stroke risk, we sought to determine whether HIV infection conferred an increased ischemic stroke risk among male veterans.<h4>Methods</h4>The Veterans Aging Cohort Study-Virtual Cohort consists of HIV-infected and uninfected veterans in care matched (1:2) for age, sex, race/ethnicity, and clinical site. We analyzed data on 76,835 male participants in the Veterans Aging Cohort Study-Virtual Cohort who ...[more]

PMID: 25862803

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Dataset Information

HIV status and the risk of ischemic stroke among men.

Objective

Methods

Results

Conclusions

Publications

HIV status and the risk of ischemic stroke among men.

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