Ontology highlight
ABSTRACT:
SUBMITTER: Winter SS
PROVIDER: S-EPMC4433576 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Winter Stuart S SS Dunsmore Kimberly P KP Devidas Meenakshi M Eisenberg Nancy N Asselin Barbara L BL Wood Brent L BL Leonard Rn Marcia S MS Murphy John J Gastier-Foster Julie M JM Carroll Andrew J AJ Heerema Nyla A NA Loh Mignon L ML Raetz Elizabeth A EA Winick Naomi J NJ Carroll William L WL Hunger Stephen P SP
Pediatric blood & cancer 20150308 7
<h4>Background</h4>Nelarabine has shown impressive single agent clinical activity in T-cell acute lymphoblastic leukemia (T-ALL), but has been associated with significant neurotoxicities in heavily pre-treated patients. We showed previously that it was safe to add nelarabine to a BFM-86 chemotherapy backbone (AALL00P2). Children's Oncology Group (COG) AALL0434 is a Phase III study designed to test the safety and efficacy of nelarabine when incorporated into a COG augmented BFM-based regimen, whi ...[more]