Temporal and spatial rearrangements of a repetitive element array on C57BL/6J mouse genome.
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ABSTRACT:
SUBMITTER: Lee KH
PROVIDER: S-EPMC4433582 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
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Temporal and spatial rearrangements of a repetitive element array on C57BL/6J mouse genome.
Lee Kang-Hoon KH Yee Lisa L Lim Debora D Greenhalgh David D Cho Kiho K
Experimental and molecular pathology 20150331 3
Repetitive elements (REs) make up the vast majority of the mammalian genomes. We identified species-specific genomic libraries of RE arrays. The non-random configurations of RE arrays suggest their functions. We tested whether RE arrays undergo age- and tissue/cell-specific rearrangements. An RE array of C57BL/6J mice, containing tandem repeats of a mosaic of transposable REs, was selected to examine rearrangements in different ages and tissues. There were marked changes in the array configurati ...[more]
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