Ontology highlight
ABSTRACT:
SUBMITTER: Chen K
PROVIDER: S-EPMC4433595 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Chen Ke K Wu Kongming K Jiao Xuanmao X Wang Liping L Ju Xiaoming X Wang Min M Di Sante Gabriele G Xu Shaohua S Wang Qiong Q Li Kevin K Sun Xin X Xu Congwen C Li Zhiping Z Casimiro Mathew C MC Ertel Adam A Addya Sankar S McCue Peter A PA Lisanti Michael P MP Wang Chenguang C Davis Richard J RJ Mardon Graeme G Pestell Richard G RG
Cancer research 20150313 10
Prostate cancer is the second leading form of cancer-related death in men. In a subset of prostate cancer patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant prostate cancer (CRPC). IL8 and IL6 are produced by prostate epithelial cells and promote prostate cancer cell invasion; however, the mechanisms restraining prostate epithelial cell cytokine secretion are poorly understood. Herein, the cell-fate determinant factor DACH1 inhibited CRPC tumor growth in mice. ...[more]