Ontology highlight
ABSTRACT:
SUBMITTER: Cebola I
PROVIDER: S-EPMC4434585 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Cebola Inês I Rodríguez-Seguí Santiago A SA Cho Candy H-H CH Bessa José J Rovira Meritxell M Luengo Mario M Chhatriwala Mariya M Berry Andrew A Ponsa-Cobas Joan J Maestro Miguel Angel MA Jennings Rachel E RE Pasquali Lorenzo L Morán Ignasi I Castro Natalia N Hanley Neil A NA Gomez-Skarmeta Jose Luis JL Vallier Ludovic L Ferrer Jorge J
Nature cell biology 20150427 5
The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of wh ...[more]