Ontology highlight
ABSTRACT:
SUBMITTER: Wiszniak S
PROVIDER: S-EPMC4434710 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Wiszniak Sophie S Mackenzie Francesca E FE Anderson Peter P Kabbara Samuela S Ruhrberg Christiana C Schwarz Quenten Q
Proceedings of the National Academy of Sciences of the United States of America 20150428 19
Jaw morphogenesis depends on the growth of Meckel's cartilage during embryogenesis. However, the cell types and signals that promote chondrocyte proliferation for Meckel's cartilage growth are poorly defined. Here we show that neural crest cells (NCCs) and their derivatives provide an essential source of the vascular endothelial growth factor (VEGF) to enhance jaw vascularization and stabilize the major mandibular artery. We further show in two independent mouse models that blood vessels promote ...[more]