Ontology highlight
ABSTRACT:
SUBMITTER: Han TH
PROVIDER: S-EPMC4434721 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Han Tae Hee TH Dharkar Poorva P Mayer Mark L ML Serpe Mihaela M
Proceedings of the National Academy of Sciences of the United States of America 20150427 19
The Drosophila larval neuromuscular junction (NMJ), at which glutamate acts as the excitatory neurotransmitter, is a widely used model for genetic analysis of synapse function and development. Despite decades of study, the inability to reconstitute NMJ glutamate receptor function using heterologous expression systems has complicated the analysis of receptor function, such that it is difficult to resolve the molecular basis for compound phenotypes observed in mutant flies. We find that Drosophila ...[more]