Ontology highlight
ABSTRACT:
SUBMITTER: Ruiz-Lafuente N
PROVIDER: S-EPMC4434814 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Ruiz-Lafuente Natalia N Alcaraz-García María-José MJ García-Serna Azahara-María AM Sebastián-Ruiz Silvia S Moya-Quiles María-Rosa MR García-Alonso Ana-María AM Parrado Antonio A
Biology open 20150410 5
Dock10 is one of the three members of the Dock-D family of Dock proteins, a class of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Its homologs Dock9 and Dock11 are Cdc42 GEFs. Dock10 is required for maintenance of rounded morphology and amoeboid-type movement. Full-length isoforms of Dock10 have been recently cloned. Here, we address GTPase specificity and GEF activity of Dock10. In order of decreasing intensity, Dock10 interacted with nucleotide-free Rac1, Cdc42, and Rac3, and mo ...[more]