Ontology highlight
ABSTRACT:
SUBMITTER: Dai X
PROVIDER: S-EPMC4434993 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Dai Xiaohua X Shen Jianbin J Annam Neeraja Priyanka NP Jiang Hong H Levi Edi E Schworer Charles M CM Tromp Gerard G Arora Anandita A Higgins Mary M Wang Xiao-Fan XF Yang Maozhou M Li Hui J HJ Zhang Kezhong K Kuivaniemi Helena H Li Li L
Scientific reports 20150518
TGF-β signaling plays critical roles in the pathogenesis of aneurysms; however, it is still unclear whether its role is protective or destructive. In this study, we investigate the role of SMAD3 in the pathogenesis of calcium chloride (CaCl2)-induced abdominal aortic aneurysms (AAA) in Smad3(-/-), Smad3(+/-) and Smad3(+/+) mice. We find that loss of SMAD3 drastically increases wall thickening of the abdominal aorta. Histological analyses show significant vessel wall remodeling with elastic fiber ...[more]