Ontology highlight
ABSTRACT:
SUBMITTER: Kirmizis A
PROVIDER: S-EPMC443521 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Kirmizis Antonis A Bartley Stephanie M SM Kuzmichev Andrei A Margueron Raphael R Reinberg Danny D Green Roland R Farnham Peggy J PJ
Genes & development 20040701 13
Polycomb group (PcG) complexes 2 and 3 are involved in transcriptional silencing. These complexes contain a histone lysine methyltransferase (HKMT) activity that targets different lysine residues on histones H1 or H3 in vitro. However, it is not known if these histones are methylation targets in vivo because the human PRC2/3 complexes have not been studied in the context of a natural promoter because of the lack of known target genes. Here we report the use of RNA expression arrays and CpG-islan ...[more]