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Calcium affinity of human ?-actinin 1.

ABSTRACT: Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of ?-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and the EF-hand motifs. Therefore, any functional or structural distinction should involve this part of the protein. To investigate this further, the calcium affinities of these three isoforms of ?-actinin 1 have been determined by isothermal calorimetry.

SUBMITTER: Backman L

PROVIDER: S-EPMC4435478 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Calcium affinity of human α-actinin 1.

Backman Lars L

PeerJ 20150507

Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of α-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. The sequence difference is located to the C-terminal domains and the EF-hand motifs. Therefore, any functional or structural distinction should involve this part of the protein. To investigate this further, the calcium affinities of these three isoforms of α-actinin 1 have been determined by isotherma ...[more]

PMID: 26020004

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