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Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder.


ABSTRACT: IMPORTANCE:Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disorders are poorly understood. OBJECTIVE:To compare intrinsic functional connectivity across the cerebral cortex in patients with schizophrenia spectrum disorders or psychotic bipolar disorder and healthy controls. DESIGN, SETTING, AND PARTICIPANTS:We studied 100 patients from an academic psychiatric hospital (28 patients with schizophrenia, 32 patients with schizoaffective disorder, and 40 patients with bipolar disorder with psychosis) and 100 healthy controls matched for age, sex, race, handedness, and scan quality from December 2009 to October 2011. MAIN OUTCOMES AND MEASURES:Functional connectivity profiles across 122 regions that covered the entire cerebral cortex. RESULTS:Relative to the healthy controls, individuals with a psychotic illness had disruption across several brain networks, with preferential reductions in functional connectivity within the frontoparietal control network (P

SUBMITTER: Baker JT 

PROVIDER: S-EPMC4435541 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder.

Baker Justin T JT   Holmes Avram J AJ   Masters Grace A GA   Yeo B T Thomas BT   Krienen Fenna F   Buckner Randy L RL   Öngür Dost D  

JAMA psychiatry 20140201 2


<h4>Importance</h4>Psychotic disorders (including schizophrenia, schizoaffective disorder, and psychotic bipolar disorder) are devastating illnesses characterized by breakdown in the integration of information processing. Recent advances in neuroimaging allow for the estimation of brain networks on the basis of intrinsic functional connectivity, but the specific network abnormalities in psychotic disorders are poorly understood.<h4>Objective</h4>To compare intrinsic functional connectivity acros  ...[more]

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