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Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces.

ABSTRACT: Our Patterning on Topography (PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial surfaces in complex geometries that are inaccessible using traditional soft lithography techniques. Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface. Here, we used this method to understand cardiomyocyte response to competing physical and chemical cues in the microenvironment.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC4435615 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Conformal nanopatterning of extracellular matrix proteins onto topographically complex surfaces.

Sun Yan Y   Jallerat Quentin Q   Szymanski John M JM   Feinberg Adam W AW  

Nature methods 20141215 2

Our Patterning on Topography (PoT) printing technique enables fibronectin, laminin and other proteins to be applied to biomaterial surfaces in complex geometries that are inaccessible using traditional soft lithography techniques. Engineering combinatorial surfaces that integrate topographical and biochemical micropatterns enhances control of the biotic-abiotic interface. Here, we used this method to understand cardiomyocyte response to competing physical and chemical cues in the microenvironmen  ...[more]

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