One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response.
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ABSTRACT:
SUBMITTER: Kannan G
PROVIDER: S-EPMC4435842 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
One minute ultraviolet exposure inhibits Toxoplasma gondii tachyzoite replication and cyst conversion without diminishing host humoral-mediated immune response.
Kannan Geetha G Prandovszky Emese E Steinfeldt Curtis B CB Gressitt Kristin L KL Yang ChunXia C Yolken Robert H RH Severance Emily G EG Jones-Brando Lorraine L Pletnikov Mikhail V MV
Experimental parasitology 20140814
We developed a protocol to inactivate Toxoplasma gondii (T. gondii) tachyzoites employing 1 min of ultraviolet (UV) exposure. We show that this treatment completely inhibited parasite replication and cyst formation in vitro and in vivo but did not affect the induction of a robust IgG response in mice. We propose that our protocol can be used to study the contribution of the humoral immune response to rodent behavioral alterations following T. gondii infection. ...[more]
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