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New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.

ABSTRACT: A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds.

SUBMITTER: Regnier T

PROVIDER: S-EPMC4436079 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors.

Regnier Thomas T Sarma Diganta D Hidaka Koushi K Bacha Usman U Freire Ernesto E Hayashi Yoshio Y Kiso Yoshiaki Y

Bioorganic & medicinal chemistry letters 20090328 10

A series of trifluoromethyl, benzothiazolyl or thiazolyl ketone-containing peptidic compounds as SARS-CoV 3CL protease inhibitors were developed and their potency was evaluated by in vitro protease inhibitory assays. Three candidates had encouraging results for the development of new anti-SARS compounds. ...[more]

PMID: 19362479

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