Dataset Information

Human papillomavirus infection and fertility alteration: a systematic review.

ABSTRACT:

Background

HPV is the most prevalent sexually transmitted infection and its effect in cancer induction is well documented. HPV infections are mostly asymptomatic, but it is unclear whether HPV infections can result in alterations of reproductive health.

Objective

To determine the relationship between human papillomavirus infections and reproductive health in both men and women.

Methods

A systematic literature review was performed in PubMed and ScienceDirect data bases from January 1994 through August 2014.

Results

HPV infections are shown to be significantly associated to many adverse effects in the reproductive function. These adverse effects were reported in different levels from cells production to pregnancy and may be related to the infecting genotype.

Conclusions

It appears from this study that HPV detection and genotyping could be of great value in infertility diagnosis at least in idiopathic infertility cases. Like for the risk of carcinogenesis, another classification of HPV regarding the risk of fertility alteration may be considered after deep investigations.

SUBMITTER: Souho T

PROVIDER: S-EPMC4436317 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Human papillomavirus infection and fertility alteration: a systematic review.

Souho Tiatou T Benlemlih Mohamed M Bennani Bahia B

PloS one 20150518 5

<h4>Background</h4>HPV is the most prevalent sexually transmitted infection and its effect in cancer induction is well documented. HPV infections are mostly asymptomatic, but it is unclear whether HPV infections can result in alterations of reproductive health.<h4>Objective</h4>To determine the relationship between human papillomavirus infections and reproductive health in both men and women.<h4>Methods</h4>A systematic literature review was performed in PubMed and ScienceDirect data bases from ...[more]

PMID: 25992782

Similar Datasets

Project description:To systematically review the published literature in order to estimate the incidence and describe the variability of human papillomavirus (HPV) infection in women following treatment for cervical neoplasia.Several scientific literature databases (e.g. PubMed, ISI Web of Science) were searched through January 31, 2012. Eligible articles provided data on (i) baseline HPV infection status within 6 months prior to or at time of treatment (pre-treatment); and (ii) HPV test results for women's first visit after treatment occurring within 36 months (post-treatment). We abstracted and summarized the post-treatment incidence of newly detected HPV genotypes that were not present at pre-treatment, overall and stratified by study and other population characteristics.A total of 25 studies were included, reporting post-treatment HPV incidence in nearly 2000 women. Mean patient age ranged from 31 to 43 years (median 36). Most studies used cervical exfoliated cell specimens to test for HPV DNA (n=20; 80%), using polymerase chain reaction (n=21; 84%). Cervical neoplasia treatment included loop electrical excision procedure (n=11; 44%); laser conization (n=2; 8%); laser ablation, surgical conization, cryotherapy, alpha-interferon (n=1; 4% each); or multiple treatment regimens (n=8; 32%). Follow-up times post-treatment ranged from 1.5 to 36 months (median 6). More than half of studies (n=17; 68%) estimated the incidence of any HPV type following treatment, while 7 (28%) focused specifically on high-risk (HR) HPV. HPV incidence after treatment varied widely, ranging from 0 to 47% (interquartile range: 0%-15%) in up to 3 years of follow-up after treatment. Lower HPV incidence was observed among studies that included relatively younger women, used laser conization, focused on HR-HPV rather than overall HPV infection, and had a lower proportion of recurrent cervical disease.These modest summary incidence estimates from the published literature can guide clinicians, epidemiologists and health economists in developing best practices for post-treatment cervical cancer prevention.

Dataset Information

Human papillomavirus infection and fertility alteration: a systematic review.

Background

Objective

Methods

Results

Conclusions

Publications

Human papillomavirus infection and fertility alteration: a systematic review.

Similar Datasets

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