Ontology highlight
ABSTRACT:
SUBMITTER: Yoo H
PROVIDER: S-EPMC4436832 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Yoo Haneul H Roth-Johnson Elizabeth A EA Bor Batbileg B Quinlan Margot E ME
Molecular biology of the cell 20150318 10
During Drosophila development, the formin actin nucleator Cappuccino (Capu) helps build a cytoplasmic actin mesh throughout the oocyte. Loss of Capu leads to female sterility, presumably because polarity determinants fail to localize properly in the absence of the mesh. To gain deeper insight into how Capu builds this actin mesh, we systematically characterized seven capu alleles, which have missense mutations in Capu's formin homology 2 (FH2) domain. We report that all seven alleles have delete ...[more]