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The Galvanotactic Migration of Keratinocytes is Enhanced by Hypoxic Preconditioning.

ABSTRACT: The endogenous electric field (EF)-directed migration of keratinocytes (galvanotaxis) into wounds is an essential step in wound re-epithelialization. Hypoxia, which occurs immediately after injury, acts as an early stimulus to initiate the healing process; however, the mechanisms for this effect, remain elusive. We show here that the galvanotactic migration of keratinocytes was enhanced by hypoxia preconditioning as a result of the increased directionality rather than the increased motility of keratinocytes. This enhancement was both oxygen tension- and preconditioning time-dependent, with the maximum effects achieved using 2% O2 preconditioning for 6?hours. Hypoxic preconditioning (2% O2, 6?hours) decreased the threshold voltage of galvanotaxis to?

SUBMITTER: Guo X

PROVIDER: S-EPMC4437307 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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The Galvanotactic Migration of Keratinocytes is Enhanced by Hypoxic Preconditioning.

Guo Xiaowei X Jiang Xupin X Ren Xi X Sun Huanbo H Zhang Dongxia D Zhang Qiong Q Zhang Jiaping J Huang Yuesheng Y

Scientific reports 20150519

The endogenous electric field (EF)-directed migration of keratinocytes (galvanotaxis) into wounds is an essential step in wound re-epithelialization. Hypoxia, which occurs immediately after injury, acts as an early stimulus to initiate the healing process; however, the mechanisms for this effect, remain elusive. We show here that the galvanotactic migration of keratinocytes was enhanced by hypoxia preconditioning as a result of the increased directionality rather than the increased motility of k ...[more]

PMID: 25988491

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