Ontology highlight
ABSTRACT:
SUBMITTER: Cirulli ET
PROVIDER: S-EPMC4437632 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Cirulli Elizabeth T ET Lasseigne Brittany N BN Petrovski Slavé S Sapp Peter C PC Dion Patrick A PA Leblond Claire S CS Couthouis Julien J Lu Yi-Fan YF Wang Quanli Q Krueger Brian J BJ Ren Zhong Z Keebler Jonathan J Han Yujun Y Levy Shawn E SE Boone Braden E BE Wimbish Jack R JR Waite Lindsay L LL Jones Angela L AL Carulli John P JP Day-Williams Aaron G AG Staropoli John F JF Xin Winnie W WW Chesi Alessandra A Raphael Alya R AR McKenna-Yasek Diane D Cady Janet J Vianney de Jong J M B JM Kenna Kevin P KP Smith Bradley N BN Topp Simon S Miller Jack J Gkazi Athina A Al-Chalabi Ammar A van den Berg Leonard H LH Veldink Jan J Silani Vincenzo V Ticozzi Nicola N Shaw Christopher E CE Baloh Robert H RH Appel Stanley S Simpson Ericka E Lagier-Tourenne Clotilde C Pulst Stefan M SM Gibson Summer S Trojanowski John Q JQ Elman Lauren L McCluskey Leo L Grossman Murray M Shneider Neil A NA Chung Wendy K WK Ravits John M JM Glass Jonathan D JD Sims Katherine B KB Van Deerlin Vivianna M VM Maniatis Tom T Hayes Sebastian D SD Ordureau Alban A Swarup Sharan S Landers John J Baas Frank F Allen Andrew S AS Bedlack Richard S RS Harper J Wade JW Gitler Aaron D AD Rouleau Guy A GA Brown Robert R Harms Matthew B MB Cooper Gregory M GM Harris Tim T Myers Richard M RM Goldstein David B DB
Science (New York, N.Y.) 20150219 6229
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment. We report the results of a moderate-scale sequencing study aimed at increasing the number of genes known to contribute to predisposition for ALS. We performed whole-exome sequencing of 2869 ALS patients and 6405 controls. Several known ALS genes were found to be associated, and TBK1 (the gene encoding TANK-binding kinase 1) was identified as an ALS gene. TBK1 is known to bind to and phosphoryla ...[more]