Dataset Information

Medial prefrontal cortical activity reflects dynamic re-evaluation during voluntary persistence.

ABSTRACT: Deciding how long to keep waiting for future rewards is a nontrivial problem, especially when the timing of rewards is uncertain. We carried out an experiment in which human decision makers waited for rewards in two environments in which reward-timing statistics favored either a greater or lesser degree of behavioral persistence. We found that decision makers adaptively calibrated their level of persistence for each environment. Functional neuroimaging revealed signals that evolved differently during physically identical delays in the two environments, consistent with a dynamic and context-sensitive reappraisal of subjective value. This effect was observed in a region of ventromedial prefrontal cortex that is sensitive to subjective value in other contexts, demonstrating continuity between valuation mechanisms involved in discrete choice and in temporally extended decisions analogous to foraging. Our findings support a model in which voluntary persistence emerges from dynamic cost/benefit evaluation rather than from a control process that overrides valuation mechanisms.

SUBMITTER: McGuire JT

PROVIDER: S-EPMC4437670 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Medial prefrontal cortical activity reflects dynamic re-evaluation during voluntary persistence.

McGuire Joseph T JT Kable Joseph W JW

Nature neuroscience 20150406 5

Deciding how long to keep waiting for future rewards is a nontrivial problem, especially when the timing of rewards is uncertain. We carried out an experiment in which human decision makers waited for rewards in two environments in which reward-timing statistics favored either a greater or lesser degree of behavioral persistence. We found that decision makers adaptively calibrated their level of persistence for each environment. Functional neuroimaging revealed signals that evolved differently d ...[more]

PMID: 25849988

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Project description:The prefrontal cortex (PFC) is thought to learn the relationships between actions and their outcomes. But little is known about what changes to population activity in PFC are specific to learning these relationships. Here we characterize the plasticity of population activity in the medial PFC (mPFC) of male rats learning rules on a Y-maze. First, we show that the population always changes its patterns of joint activity between the periods of sleep either side of a training session on the maze, regardless of successful rule learning during training. Next, by comparing the structure of population activity in sleep and training, we show that this population plasticity differs between learning and nonlearning sessions. In learning sessions, the changes in population activity in post-training sleep incorporate the changes to the population activity during training on the maze. In nonlearning sessions, the changes in sleep and training are unrelated. Finally, we show evidence that the nonlearning and learning forms of population plasticity are driven by different neuron-level changes, with the nonlearning form entirely accounted for by independent changes to the excitability of individual neurons, and the learning form also including changes to firing rate couplings between neurons. Collectively, our results suggest two different forms of population plasticity in mPFC during the learning of action-outcome relationships: one a persistent change in population activity structure decoupled from overt rule-learning, and the other a directional change driven by feedback during behavior.SIGNIFICANCE STATEMENT The PFC is thought to represent our knowledge about what action is worth doing in which context. But we do not know how the activity of neurons in PFC collectively changes when learning which actions are relevant. Here we show, in a trial-and-error task, that population activity in PFC is persistently changing, regardless of learning. Only during episodes of clear learning of relevant actions are the accompanying changes to population activity carried forward into sleep, suggesting a long-lasting form of neural plasticity. Our results suggest that representations of relevant actions in PFC are acquired by reward imposing a direction onto ongoing population plasticity.

Dataset Information

Medial prefrontal cortical activity reflects dynamic re-evaluation during voluntary persistence.

Publications

Medial prefrontal cortical activity reflects dynamic re-evaluation during voluntary persistence.

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