Ontology highlight
ABSTRACT:
SUBMITTER: Guan PP
PROVIDER: S-EPMC4438667 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Guan Pei-Pei PP Guo Jing-Wen JW Yu Xin X Wang Yue Y Wang Tao T Konstantopoulos Konstantinos K Wang Zhan-You ZY Wang Pu P
Scientific reports 20150520
MMP-1 expression is detected in fluid shear stress (20 dyn/cm(2))-activated and osteoarthritic human chondrocytes, however, the precise mechanisms underlying shear-induced MMP-1 synthesis remain unknown. Using primary chondrocytes and T/C-28a2 chondrocytic cells as model systems, we report that prolonged application of high fluid shear to human chondrocytes induced the synthesis of cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β) and fibroblast growth factor-2 (FGF-2), which led to a marked incr ...[more]