Ontology highlight
ABSTRACT:
SUBMITTER: Bergenfelz C
PROVIDER: S-EPMC4439153 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bergenfelz Caroline C Larsson Anna-Maria AM von Stedingk Kristoffer K Gruvberger-Saal Sofia S Aaltonen Kristina K Jansson Sara S Jernström Helena H Janols Helena H Wullt Marlene M Bredberg Anders A Rydén Lisa L Leandersson Karin K
PloS one 20150520 5
Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenoty ...[more]