Ontology highlight
ABSTRACT:
SUBMITTER: Nakamura T
PROVIDER: S-EPMC4439210 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nakamura Takahisa T Kunz Ryan C RC Zhang Cai C Kimura Taishi T Yuan Celvie L CL Baccaro Brenna B Namiki Yuka Y Gygi Steven P SP Hotamisligil Gökhan S GS
Cell reports 20150402 2
Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent kinase (PKR) has been proposed to play an important role in integrating these pathways. Here, we report the formation of a complex between PKR and TAR RNA-binding protein (TRBP) during metabolic and obesity-induced stress, which is critical for the regulation of eukaryotic translation initiation factor 2 alpha (eIF2α) phosphorylation and c-Jun ...[more]