Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC4439324 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Zhao Yimeng Y Riley Nicholas M NM Sun Liangliang L Hebert Alexander S AS Yan Xiaojing X Westphall Michael S MS Rush Matthew J P MJ Zhu Guijie G Champion Matthew M MM Mba Medie Felix F Champion Patricia A DiGiuseppe PA Coon Joshua J JJ Dovichi Norman J NJ
Analytical chemistry 20150506 10
Top-down proteomics offers the potential for full protein characterization, but many challenges remain for this approach, including efficient protein separations and effective fragmentation of intact proteins. Capillary zone electrophoresis (CZE) has shown great potential for separation of intact proteins, especially for differentially modified proteoforms of the same gene product. To date, however, CZE has been used only with collision-based fragmentation methods. Here we report the first imple ...[more]