Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.
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ABSTRACT:
SUBMITTER: Xia M
PROVIDER: S-EPMC4439390 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.
Xia Meng M Abazyan Sofya S Jouroukhin Yan Y Pletnikov Mikhail M
Schizophrenia research 20141120 1
Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Until recently, there has been the paucity of experimental approaches to studying the roles of astrocytes in behavioral disease. A new generation of in vivo models allows us to advanc ...[more]
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