Ontology highlight
ABSTRACT:
SUBMITTER: Ye Q
PROVIDER: S-EPMC4439613 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Ye Qiaozhen Q Rosenberg Scott C SC Moeller Arne A Speir Jeffrey A JA Su Tiffany Y TY Corbett Kevin D KD
eLife 20150428
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein remodelers NSF and p97, while its overall hexameric architecture and likely structural mechanism bear ...[more]