StIL-17 gene polymorphisms in the development of pulmonary tuberculosis.

ABSTRACT: We conduct a case-control study to explore the possible association between IL-17 gene polymorphisms and development of TB.The study population comprised 428 TB subjects and 428 control subjects between January 2013 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 and rs9382084 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism (PCR-RFLP).The TB cases were more likely to have a habit of smoking when comparing with controls. By conditional logistic regression analysis, individuals carrying CC genotype of rs763780 were more likely to have a significantly increased risk of TB when compared with TT genotype. The OR (95% CI) for CC genotype of rs763780 was 2.98 (1.58-5.92).In conclusion, we suggest that rs763780 play a critical role in the etiology of TB. These findings could be helpful in identifying individuals at increased risk for developing TB.

SUBMITTER: Du J 

PROVIDER: S-EPMC4440154 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature