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Behavioral disturbances in estrogen-related receptor alpha-null mice.

ABSTRACT: Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null female mice display a reduced operant response to a high-fat diet, compulsivity/behavioral rigidity, and social deficits. Selective Esrra knockdown in the prefrontal and orbitofrontal cortices of adult female mice recapitulates reduced operant response and increased compulsivity, respectively. These results indicate that Esrra deficiency in the mouse brain impairs behavioral responses in multiple functional domains.

SUBMITTER: Cui H

PROVIDER: S-EPMC4440329 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Behavioral disturbances in estrogen-related receptor alpha-null mice.

Cui Huxing H Lu Yuan Y Khan Michael Z MZ Anderson Rachel M RM Anderson Rachel M RM McDaniel Latisha L Wilson Hannah E HE Yin Terry C TC Radley Jason J JJ Pieper Andrew A AA Lutter Michael M

Cell reports 20150409 3

Eating disorders, such as anorexia nervosa and bulimia nervosa, are common and severe mental illnesses of unknown etiology. Recently, we identified a rare missense mutation in the transcription factor estrogen-related receptor alpha (ESRRA) that is associated with the development of eating disorders. However, little is known about ESRRA function in the brain. Here, we report that Esrra is expressed in the mouse brain and demonstrate that Esrra levels are regulated by energy reserves. Esrra-null ...[more]

PMID: 25865889

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Project description:ERα is a major driver for breast cancer initiation and progression.However,the fundamental mechanisms,including global cistromic and genomic transcriptional responses that are required to elicit breast cancer initiation and progression in response to ERα, have not been elucidated. We used chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) to identify estrogen regulated genes that directly recruit ERα in the p53 null mouse mammary gland

2022-02-06 | GSE77977 | GEO

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