Ontology highlight
ABSTRACT:
SUBMITTER: LeBlanc ME
PROVIDER: S-EPMC4440747 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
LeBlanc Michelle E ME Wang Weiwen W Caberoy Nora B NB Chen Xiuping X Guo Feiye F Alvarado Gabriela G Shen Chen C Wang Feng F Wang Hui H Chen Rui R Liu Zhao-Jun ZJ Webster Keith K Li Wei W
PloS one 20150521 5
Hepatoma-derived growth factor-related protein-3 (Hdgfrp3 or HRP-3) was recently reported as a neurotrophic factor and is upregulated in hepatocellular carcinoma to promote cancer cell survival. Here we identified HRP-3 as a new endothelial ligand and characterized its in vitro and in vivo functional roles and molecular signaling. We combined open reading frame phage display with multi-round in vivo binding selection to enrich retinal endothelial ligands, which were systematically identified by ...[more]