Ontology highlight
ABSTRACT:
SUBMITTER: Corrales L
PROVIDER: S-EPMC4440852 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Corrales Leticia L Glickman Laura Hix LH McWhirter Sarah M SM Kanne David B DB Sivick Kelsey E KE Katibah George E GE Woo Seng-Ryong SR Lemmens Edward E Banda Tamara T Leong Justin J JJ Metchette Ken K Dubensky Thomas W TW Gajewski Thomas F TF
Cell reports 20150507 7
Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-resident dendritic cells. On the basis of recent observations indicating that IFN-β expression was dependent upon activation of the host STING pathway, we hypothesized that direct engagement of STING through intratumoral (IT) administration of specific agonists would result in effective anti-tumor therapy. After proof-of-principle studies using the mouse STING agonist DMXAA showed a potent therapeutic effect, we ...[more]