Interaction of age with lipoproteins as predictors of aortic valve calcification in the multi-ethnic study of atherosclerosis.

ABSTRACT:

Background

Previous epidemiologic studies have shown that low-density lipoprotein is an independent risk factor for prevalent aortic valve calcification (AVC); however, to our knowledge, the interactions between plasma lipoprotein concentrations and age on the relative risks (RRs) for AVC prevalence and severity have not been examined in a large, racially and ethnically diverse cohort.

Methods

Using stepwise RR regression, the relationships of baseline fasting lipid levels and lipoprotein levels to baseline prevalence and severity of AVC were determined in 5801 non-statin-using participants in the Multi-Ethnic Study of Atherosclerosis (MESA).

Results

In age-stratified, adjusted analyses, the low-density lipoprotein-associated RRs (95% confidence intervals) for prevale

SUBMITTER: Owens DS 

PROVIDER: S-EPMC4441013 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature