Detecting differential patterns of interaction in molecular pathways.
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ABSTRACT:
SUBMITTER: Yajima M
PROVIDER: S-EPMC4441103 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Publications
Detecting differential patterns of interaction in molecular pathways.
Yajima Masanao M Telesca Donatello D Ji Yuan Y Müller Peter P
Biostatistics (Oxford, England) 20141216 2
We consider statistical inference for potentially heterogeneous patterns of association characterizing the expression of bio-molecular pathways across different biologic conditions. We discuss a modeling approach based on Gaussian-directed acyclic graphs and provide computational and methodological details needed for posterior inference. Our application finds motivation in reverse phase protein array data from a study on acute myeloid leukemia, where interest centers on contrasting refractory ve ...[more]
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