Ontology highlight
ABSTRACT:
SUBMITTER: Cheng S
PROVIDER: S-EPMC4441131 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cheng Shanshan S Hou Jinxing J Zhang Chen C Xu Congyu C Wang Long L Zou Xiaoxia X Yu Huahong H Shi Yun Y Yin Zhenyu Z Chen Guiquan G
Scientific reports 20150522
Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models of neurological diseases. However, it remained unknown whether minocycline is effective to prevent neuron loss. To systematically evaluate its effects, minocycline was used to treat Dicer conditional knockout (cKO) mice which display age-related neuron loss. The drug was given to mutant mice prior to the occurrence of neuro ...[more]