Ontology highlight
ABSTRACT:
SUBMITTER: Pele L
PROVIDER: S-EPMC4441531 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nanomedicine (London, England) 20140703 9
<h4>Aim</h4>To determine whether in vitro experimental conditions dictate cellular activation of the inflammasome by apatitic calcium phosphate nanoparticles.<h4>Material & methods</h4>The responses of blood-derived primary human cells to in situ-formed apatite were investigated under different experimental conditions to assess the effect of aseptic culture, cell rest and duration of particle exposure. Cell death and particle uptake were assessed, while IL-1β and caspase 1 responses, with and wi ...[more]