Ontology highlight
ABSTRACT:
SUBMITTER: Joglekar MV
PROVIDER: S-EPMC4441624 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Joglekar M V MV Quintana Diez P M PM Marcus S S Qi R R Espinasse B B Wiesner M R MR Pempe E E Liu J J Monroe D M DM Arepally G M GM
Thrombosis and haemostasis 20120208 4
Recent studies have shown that ultra-large complexes (ULCs) of platelet factor 4 (PF4) and heparin (H) play an essential role in the pathogenesis of heparin-induced thrombocytopenia (HIT), an immune-mediated disorder caused by PF4/H antibodies. Because antigenic PF4/H ULCs assemble through non-specific electrostatic interactions, we reasoned that disruption of charge-based interactions can modulate the immune response to antigen. We tested a minimally anticoagulant compound (2-O, 3-O desulfated ...[more]