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Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia.

ABSTRACT: We recently published genetic lineage-tracing experiments using the Fezf2 and Cux2 loci. These experiments demonstrated that at both the clonal and population levels Fezf2(+) RGCs are multipotent and that at the population level Cux2(+) RGCs are multipotent. Here, we extend our work on the lineages of Fezf2(+) and Cux2(+) RGCs. Clonal analysis of E10.5 neocortical progenitors suggests that most, if not all, Cux2(+) and Fezf2(+) RGCs generate diverse projection neuron subtypes located throughout layers 2-6. These results support our previous conclusion that both Fezf2(+) and Cux2(+) RGCs are multipotent neocortical progenitors. This Matters Arising Response paper addresses the Gil-Sanz et al. (2015) Matters Arising paper, published concurrently in Neuron.

SUBMITTER: Eckler MJ

PROVIDER: S-EPMC4441766 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Cux2-positive radial glial cells generate diverse subtypes of neocortical projection neurons and macroglia.

Eckler Matthew J MJ Nguyen Ton D TD McKenna William L WL Fastow Ben L BL Guo Chao C Rubenstein John L R JLR Chen Bin B

Neuron 20150501 4

We recently published genetic lineage-tracing experiments using the Fezf2 and Cux2 loci. These experiments demonstrated that at both the clonal and population levels Fezf2(+) RGCs are multipotent and that at the population level Cux2(+) RGCs are multipotent. Here, we extend our work on the lineages of Fezf2(+) and Cux2(+) RGCs. Clonal analysis of E10.5 neocortical progenitors suggests that most, if not all, Cux2(+) and Fezf2(+) RGCs generate diverse projection neuron subtypes located throughout ...[more]

PMID: 25996137

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