Vitamin D-binding protein and pancreatic cancer: a nested case-control study.

ABSTRACT:

Background

Vitamin D-binding protein (DBP) is the primary carrier of 25-hydroxyvitamin D [25(OH)D] in the circulation. One prospective study in male smokers found a protective association between DBP and pancreatic cancer, particularly among men with higher 25(OH)D concentrations.

Objective

The objective was to examine the association between DBP and pancreatic cancer risk in an American population.

Design

We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer screening trial cohort of men and women aged 55-74 y at baseline. Between 1993 and 2010, 295 incident pancreatic adenocarcinoma cases were reported (follow-up to 15.1 y). Two controls (n = 590) were matched to each case by age, race, sex, and month of blood draw. We calcul

SUBMITTER: Piper MR 

PROVIDER: S-EPMC4441803 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature