Ontology highlight
ABSTRACT:
SUBMITTER: Ma DK
PROVIDER: S-EPMC4441829 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Cell 20150514 5
Cells adapt to temperature shifts by adjusting levels of lipid desaturation and membrane fluidity. This fundamental process occurs in nearly all forms of life, but its mechanism in eukaryotes is unknown. We discovered that the evolutionarily conserved Caenorhabditis elegans gene acdh-11 (acyl-CoA dehydrogenase [ACDH]) facilitates heat adaptation by regulating the lipid desaturase FAT-7. Human ACDH deficiency causes the most common inherited disorders of fatty acid oxidation, with syndromes that ...[more]