Ontology highlight
ABSTRACT:
SUBMITTER: Lekic T
PROVIDER: S-EPMC4442059 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Lekic Tim T Klebe Damon D McBride Devin W DW Manaenko Anatol A Rolland William B WB Flores Jerry J JJ Altay Orhan O Tang Jiping J Zhang John H JH
Stroke 20150430 6
<h4>Background and purpose</h4>This study examines the role of thrombin's protease-activated receptor (PAR)-1, PAR-4 in mediating cyclooxygenase-2 and mammalian target of rapamycin after germinal matrix hemorrhage.<h4>Methods</h4>Germinal matrix hemorrhage was induced by intraparenchymal infusion of bacterial collagenase into the right ganglionic eminence of P7 rat pups. Animals were treated with PAR-1, PAR-4, cyclooxygenase-2, or mammalian target of rapamycin inhibitors by 1 hour, and ≤5 days.< ...[more]